Answer: Because, like all big companies, Eli Lilly can only handle a certain level of creativity. Big companies thrive and prosper on the systems they put in place to serve their markets efficiently. They don't want the messy activity that surrounds inventing a whole new way of doing things. Big companies want to keep doing what they do best and when they see a new idea working, they buy it -- lock, stock and barrel.

To work on a new idea, unfettered by protocol, is what every entrepreneur needs so we have to leave the comfort of the paycheck.

You think about it: What's your next new thing?